AWS-native startups should prioritize GenAI use cases that deliver measurable revenue or cost impact by assessing business needs, data readiness, and feasibility. Leveraging AWS tools like SageMaker, Bedrock, and Kendra enables scalable AI solutions. Effective cost management via FinOps, ensuring security compliance (SOC 2, ISO 27001), and strategic build-versus-buy decisions are key to sustainable GenAI adoption and business growth.