AWS-native startups should prioritize AI use cases by assessing business value, feasibility, risk, and speed of impact. Use AWS tools like SageMaker and Bedrock, manage security and costs, and validate ROI with pilots to optimize resources and outcomes.

Guide AWS-native startups to prioritize AI projects linked to revenue and operations using a value stack framework; focus on measurable goals, GenAI pilots, security, compliance, and governance for scalable, secure growth.